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Article

Effects of single-nucleotide polymorphisms in the mTORC1 pathway on the risk of brain metastasis in patients with non-small cell lung cancer.

Journal of cancer research and clinical oncology - 1 Jan 2020

Xu Yiquan, Huang Yina, Weng Lihong, Zheng Jiankun, Huang Yi, Lin Ying, Zhao Yunan, Li Hongru, Chen Yusheng

Abstract excerpt

PURPOSE: The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway plays a vital role in cancer development and progression. This study aimed to investigate the relationship between genotype variants in mTORC1 pathway and the risk of brain metastasis (BM) in patients with non-small cell lung cancer (NSCLC). METHODS: We extracted genomic DNA from blood samples of 501 NSCLC patients and genotyped eight...

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Identifiers

PMID: 31641854
DOI: 10.1007/s00432-019-03059-y
PMCID: PMC6942024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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