Article
Genome-wide association analyses of invasive pneumococcal isolates identify a missense bacterial mutation associated with meningitis.
Nature communications - 14 Jan 2019
Li Yuan, Metcalf Benjamin J, Chochua Sopio, Li Zhongya, Walker Hollis, Tran Theresa, Hawkins Paulina A, Gierke Ryan, Pilishvili Tamara, McGee Lesley, Beall Bernard W
Abstract excerpt
Bacterial mutations predisposing pneumococcus to causing meningitis, a more severe form of invasive pneumococcal disease (IPD), are largely unknown. Knowledge of such mutations may improve our understanding of pathogenesis and inform preventive strategies. Here we report a pneumococcal pbp1b gene mutation (pbp1bA641C causing N214T change in PBP1b transglycosylase domain) that is associated with meningitis in an...
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