The Contribution of Genetic Variation of Streptococcus pneumoniae to the Clinical Manifestation of Invasive Pneumococcal Disease.

doi:10.1093/cid/ciy417

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Article

The Contribution of Genetic Variation of Streptococcus pneumoniae to the Clinical Manifestation of Invasive Pneumococcal Disease.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jan 2019

Cremers Amelieke J H, Mobegi Fredrick M, van der Gaast-de Jongh Christa, van Weert Michelle, van Opzeeland Fred J, Vehkala Minna, Knol Mirjam J, Bootsma Hester J, Välimäki Niko, Croucher Nicholas J, Meis Jacques F, Bentley Stephen, van Hijum Sacha A F T, Corander Jukka, Zomer Aldert L, Ferwerda Gerben, de Jonge Marien I

Abstract excerpt

Background: Different clinical manifestations of invasive pneumococcal disease (IPD) have thus far mainly been explained by patient characteristics. Here we studied the contribution of pneumococcal genetic variation to IPD phenotype. Methods: The index cohort consisted of 349 patients admitted to 2 Dutch hospitals between 2000-2011 with pneumococcal bacteremia. We performed genome-wide association studies to...

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PMID: 29788414
DOI: 10.1093/cid/ciy417

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