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Article

Crystal structure of penicillin-binding protein 1a (PBP1a) reveals a mutational hotspot implicated in beta-lactam resistance in Streptococcus pneumoniae.

Journal of molecular biology - 27 Jan 2006

Contreras-Martel Carlos, Job Viviana, Di Guilmi Anne Marie, Vernet Thierry, Dideberg Otto, Dessen Andréa

Abstract excerpt

Streptococcus pneumoniae is a major human pathogen whose infections have been treated with beta-lactam antibiotics for over 60 years, but the proliferation of strains that are highly resistant to such drugs is a problem of worldwide concern. Beta-lactams target penicillin-binding proteins (PBPs), membrane-associated enzymes that play essential roles in the peptidoglycan biosynthetic process. Bifunctional PBPs...

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Identifiers

PMID: 16316661
DOI: 10.1016/j.jmb.2005.10.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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