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Article

Penicillin-Binding Protein Transpeptidase Signatures for Tracking and Predicting β-Lactam Resistance Levels in Streptococcus pneumoniae.

mBio - 14 Jun 2016

Li Yuan, Metcalf Benjamin J, Chochua Sopio, Li Zhongya, Gertz Robert E, Walker Hollis, Hawkins Paulina A, Tran Theresa, Whitney Cynthia G, McGee Lesley, Beall Bernard W

Abstract excerpt

UNLABELLED: β-Lactam antibiotics are the drugs of choice to treat pneumococcal infections. The spread of β-lactam-resistant pneumococci is a major concern in choosing an effective therapy for patients. Systematically tracking β-lactam resistance could benefit disease surveillance. Here we developed a classification system in which a pneumococcal isolate is assigned to a "PBP type" based on sequence signatures in...

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Identifiers

PMID: 27302760
DOI: 10.1128/mBio.00756-16
PMCID: PMC4916381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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