Article

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

2018-08-07

Abstract excerpt

Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a genome-wide association study of human and pathogen we show that human variation explains almost half of variation in su...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2e2f978-fad3-5a3e-b07f-faa67a82027a
DOI: 10.1101/386078

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitisDOI 10.1101/386078Read

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitisSemantic proximity Read

Disease-Associated Streptococcus pneumoniae Genetic Variation.Semantic proximity Read

Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis.Semantic proximity Read

The contribution of genetic variation of <i>Streptococcus pneumoniae</i> to the clinical manifestation of invasive pneumococcal diseaseSemantic proximity Read

Streptococcus pneumoniae: virulence factors and variation.Semantic proximity Read

A genome-wide association study of emm89 Streptococcus pyogenes identifies genetic variations contributing to severe invasive infectionsSemantic proximity Read

Genome-wide association, prediction and heritability in bacteriaSemantic proximity Read

Genome-wide association study of susceptibility to pneumococcal carriage amongst childrenSemantic proximity Read

The Contribution of Genetic Variation of Streptococcus pneumoniae to the Clinical Manifestation of Invasive Pneumococcal Disease.Semantic proximity Read

Host-pathogen interactions revealed by human genome-wide surveys.Semantic proximity Read

Identifying <i>Streptococcus pneumoniae</i> genes associated with invasive disease using pangenome-based whole genome sequence typingSemantic proximity Read

Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease.Semantic proximity Read