Article
Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism.
Communications biology - 8 Oct 2020
Chaguza Chrispin, Yang Marie, Cornick Jennifer E, du Plessis Mignon, Gladstone Rebecca A, Kwambana-Adams Brenda A, Lo Stephanie W, Ebruke Chinelo, Tonkin-Hill Gerry, Peno Chikondi, Senghore Madikay, Obaro Stephen K, Ousmane Sani, Pluschke Gerd, Collard Jean-Marc, Sigaùque Betuel, French Neil, Klugman Keith P, Heyderman Robert S, McGee Lesley, Antonio Martin, Breiman Robert F, von Gottberg Anne, Everett Dean B, Kadioglu Aras, Bentley Stephen D
Abstract excerpt
Hyper-virulent Streptococcus pneumoniae serotype 1 strains are endemic in Sub-Saharan Africa and frequently cause lethal meningitis outbreaks. It remains unknown whether genetic variation in serotype 1 strains modulates tropism into cerebrospinal fluid to cause central nervous system (CNS) infections, particularly meningitis. Here, we address this question through a large-scale linear mixed model genome-wide...
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