Article
Genome-wide association study identifies five new breast cancer susceptibility loci.
Nature genetics - 1 Jun 2010
Turnbull Clare, Ahmed Shahana, Morrison Jonathan, Pernet David, Renwick Anthony, Maranian Mel, Seal Sheila, Ghoussaini Maya, Hines Sarah, Healey Catherine S, Hughes Deborah, Warren-Perry Margaret, Tapper William, Eccles Diana, Evans D Gareth, Hooning Maartje, Schutte Mieke, van den Ouweland Ans, Houlston Richard, Ross Gillian, Langford Cordelia, Pharoah Paul D P, Stratton Michael R, Dunning Alison M, Rahman Nazneen, Easton Douglas F
Abstract excerpt
Breast cancer is the most common cancer in women in developed countries. To identify common breast cancer susceptibility alleles, we conducted a genome-wide association study in which 582,886 SNPs were genotyped in 3,659 cases with a family history of the disease and 4,897 controls. Promising associations were evaluated in a second stage, comprising 12,576 cases and 12,223 controls. We identified five new...
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