Article
Genome-wide association study of breast cancer in Latinas identifies novel protective variants on 6q25.
Nature communications - 20 Oct 2014
Fejerman Laura, Ahmadiyeh Nasim, Hu Donglei, Huntsman Scott, Beckman Kenneth B, Caswell Jennifer L, Tsung Karen, John Esther M, Torres-Mejia Gabriela, Carvajal-Carmona Luis, Echeverry María Magdalena, Tuazon Anna Marie D, Ramirez Carolina, Gignoux Christopher R, Eng Celeste, Gonzalez-Burchard Esteban, Henderson Brian, Le Marchand Loic, Kooperberg Charles, Hou Lifang, Agalliu Ilir, Kraft Peter, Lindström Sara, Perez-Stable Eliseo J, Haiman Christopher A, Ziv Elad
Abstract excerpt
The genetic contributions to breast cancer development among Latinas are not well understood. Here we carry out a genome-wide association study of breast cancer in Latinas and identify a genome-wide significant risk variant, located 5' of the Estrogen Receptor 1 gene (ESR1; 6q25 region). The minor allele for this variant is strongly protective (rs140068132: odds ratio (OR) 0.60, 95% confidence interval (CI)...
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