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Colorectal cancer: the APC-lncRNA link

13 Jan 2019

Abstract excerpt

The adenomatous polyposis coli (APC) gene plays, among other things, a crucial role in the regulation of cell proliferation and survival through its ability to regulate canonical Wnt signaling. In this issue of the JCI, Wang et al. provide an intriguing new mechanism for APC function involving the regulation of a novel long noncoding RNA (lncRNA), leading to changes in exosome production. APC signaling via this...

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PMID: 30640173
DOI: 10.1172/jci125985

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