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Article

Identify CCL20 as the key immune microenvironment regulator in APC-mutation colon cancer by sc-RNA data analysis.

Biochemical pharmacology - 1 Aug 2026

Shi Xianli, Chen Haoming, Li Rui, Zhong Ziyue, Lu Xiaoqing, Kong Xueqing, Li Jiangchao, Wang Shanshan, Guo Wenjing, Zhang Rongxin

Abstract excerpt

The inactivation of the APC gene is strongly associated with the initiation and progression of Colorectal Cancer (CRC). However, the specific role of Adenomatous Polyposis Coli (APC) inactivation in CRC development and its regulation of the Tumor Microenvironment (TME) remains poorly understood. In this study, we identified a distinctive feature of the APCm+ CRC-specific TME, characterized by an enrichment of T...

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Adenomatous Polyposis Coli Protein
Colonic Neoplasms
Gene Expression Regulation, Neoplastic
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Microenvironment

Source

Identifiers

PMID: 42002233
DOI: 10.1016/j.bcp.2026.117992

Genes

APC
CCL20
CCR6
GC
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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