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Article

Whole genomes define concordance of matched primary, xenograft, and organoid models of pancreas cancer

10 Jan 2019

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis among solid malignancies and improved therapeutic strategies are needed to improve outcomes. Patient-derived xenografts (PDX) and patient-derived organoids (PDO) serve as promising tools to identify new drugs with therapeutic potential in PDAC. For these preclinical disease models to be effective, they should both recapitulate the molecular...

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PMID: 30629588
DOI: 10.1371/journal.pcbi.1006596

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