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Article

Tumor organoids improve mutation detection of pancreatic ductal adenocarcinoma.

Scientific reports - 26 Oct 2024

Farshadi Elham Aida, Wang Wenya, Mohammad Farzana, van der Oost Elise, Doukas Michail, van Eijck Casper H J, van de Werken Harmen J G, Katsikis Peter D

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) presents challenges in detecting somatic mutations due to its complex cellular composition. This study investigated the utility of patient-derived organoids (PDOs) to overcome these obstacles and enhance somatic mutation identification. Surgically resected PDAC tumors and their paired PDOs from 21 patients were examined. Whole-exome sequencing (WES) of tumor tissue,...

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Source

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Identifiers

PMID: 39462012
DOI: 10.1038/s41598-024-75888-y
PMCID: PMC11513084

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