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Article

Pancreatic cancer cell lines as patient-derived avatars: genetic characterisation and functional utility.

Gut - 1 Mar 2018

Knudsen Erik S, Balaji Uthra, Mannakee Brian, Vail Paris, Eslinger Cody, Moxom Christopher, Mansour John, Witkiewicz Agnieszka K

Abstract excerpt

OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a therapy recalcitrant disease with the worst survival rate of common solid tumours. Preclinical models that accurately reflect the genetic and biological diversity of PDAC will be important for delineating features of tumour biology and therapeutic vulnerabilities. DESIGN: 27 primary PDAC tumours were employed for genetic analysis and development of tumour...

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Identifiers

PMID: 28073890
DOI: 10.1136/gutjnl-2016-313133
PMCID: PMC5868284

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