Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin

3 Jan 2019

Abstract excerpt

Although numerous therapeutic strategies have attempted to target aerobic glycolysis to inhibit tumor progression, these approaches have not resulted in effective clinical outcomes. Murine squamous cell carcinoma (SCC) can be initiated by hair follicle stem cells (HFSCs). HFSCs utilize aerobic glycolysis, and the activity of lactate dehydrogenase (Ldh) is essential for HFSC activation. We sought to determine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30626875
DOI: 10.1038/s41467-018-07857-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of originPMID 30626875Read ↗

Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinomaSemantic proximity Read ↗

Lactate dehydrogenase activity drives hair follicle stem cell activation.Semantic proximity Read ↗

Lactate-Driven Heterogeneity of Immune Checkpoint Expression in Breast and Lung Cancer Cell LinesSemantic proximity Read ↗

Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma DevelopmentSemantic proximity Read ↗

Chronic Alcohol Exposure Promotes Cancer Stemness and Glycolysis in Oral/Oropharyngeal Squamous Cell Carcinoma Cell Lines by Activating NFAT SignalingSemantic proximity Read ↗

XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas.Semantic proximity Read ↗

EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect.Semantic proximity Read ↗

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for TransformationSemantic proximity Read ↗

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.Semantic proximity Read ↗

Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar.Semantic proximity Read ↗

Lactate derived from CAFs mediates H3K18la in stemness gene promoters, which promotes tumor malignant phenotype formation.Semantic proximity Read ↗

Targeting the glucose-insulin link in head and neck squamous cell carcinoma induces cytotoxic oxidative stress and inhibits cancer growthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.