Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lactate derived from CAFs mediates H3K18la in stemness gene promoters, which promotes tumor malignant phenotype formation.

Molecular genetics and genomics : MGG - 7 Aug 2026

Yao Jie, Li Guangbin, Chen Ke, Wang Yuxuan, Lu Xiaochen, Li Jiaxi, Ma Haitao

Abstract excerpt

Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer, characterized by high invasiveness, poor prognosis, and limited therapeutic options. Cancer-associated fibroblasts (CAFs), as a core component of the tumor microenvironment (TME), have been shown to promote the malignant progression of NSCLC, but the specific regulatory mechanisms remain incompletely understood. This study aims to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-Associated Fibroblasts
Share to Carcinoma, Non-Small-Cell Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Movement

Share to Epithelial-Mesenchymal Transition

Share to Histones

Share to Lactic Acid

Share to Neoplastic Stem Cells

Share to Tumor Microenvironment

Source

Identifiers

PMID: 42562962
DOI: 10.1007/s00438-026-02460-w

Genes

CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lactate derived from CAFs mediates H3K18la in stemness gene promoters, which promotes tumor malignant phenotype formation.PMID 42562962Read ↗

Cancer-associated fibroblasts promote EGFR-TKI resistance via the CTHRC1/glycolysis/H3K18la positive feedback loopSemantic proximity Read ↗

Lactate-related gene signatures predict prognosis and immune profiles in esophageal squamous cell carcinomaSemantic proximity Read ↗

FRK plays an oncogenic role in non‐small cell lung cancer by enhancing the stemness phenotype via induction of metabolic reprogrammingSemantic proximity Read ↗

Histone lactylation-related genes correlate with the molecular patterns and functions of cancer-associated fibroblasts and have significant clinical implications in clear cell renal cell carcinomaSemantic proximity Read ↗

Transmembrane Serine Protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in lung squamous cell carcinomaSemantic proximity Read ↗

Lactate-Driven Heterogeneity of Immune Checkpoint Expression in Breast and Lung Cancer Cell LinesSemantic proximity Read ↗

Lactate Increases Stemness of CD8 <sup>+</sup> T Cells to Augment Anti-Tumor ImmunitySemantic proximity Read ↗

NSCLC presents metabolic heterogeneity, and there is still some leeway for EGF stimuli in EGFR-mutated NSCLC.Semantic proximity Read ↗

PHF5A Contributes to the Maintenance of the Cancer Stem-like Phenotype in Non-Small Cell Lung Cancer by Regulating Histone Deacetylase 8.Semantic proximity Read ↗

Tumor-derived lactate promotes resistance to bevacizumab treatment by facilitating autophagy enhancer protein RUBCNL expression through histone H3 lysine 18 lactylation (H3K18la) in colorectal cancerSemantic proximity Read ↗

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblastsSemantic proximity Read ↗

Research Progress of Lactate and Its Regulated Small Molecule DrugsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.