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Article

EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect.

Oncotarget - 7 Feb 2017

Xu Qilin, Zhang Qunzhou, Ishida Yasutaka, Hajjar Souren, Tang Xudong, Shi Haoran, Dang Chi V, Le Anh D

Abstract excerpt

"Warburg effect", the enhanced glycolysis or aerobic glycolysis, confers cancer cells the ability to survive and proliferate even under stressed conditions. In this study, we explored the role of epidermal growth factor (EGF) in orchestrating Warburg effect, the epithelial-mesenchymal transition (EMT) process, and the acquisition of cancer stem-like cell properties in human oral squamous cell carcinoma (OSCC)...

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Source

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Identifiers

PMID: 27926487
DOI: 10.18632/oncotarget.13771
PMCID: PMC5354753

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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