Article
Lactate dehydrogenase activity drives hair follicle stem cell activation.
Nature cell biology - 1 Sept 2017
Flores Aimee, Schell John, Krall Abigail S, Jelinek David, Miranda Matilde, Grigorian Melina, Braas Daniel, White Andrew C, Zhou Jessica L, Graham Nicholas A, Graeber Thomas, Seth Pankaj, Evseenko Denis, Coller Hilary A, Rutter Jared, Christofk Heather R, Lowry William E
Abstract excerpt
Although normally dormant, hair follicle stem cells (HFSCs) quickly become activated to divide during a new hair cycle. The quiescence of HFSCs is known to be regulated by a number of intrinsic and extrinsic mechanisms. Here we provide several lines of evidence to demonstrate that HFSCs utilize glycolytic metabolism and produce significantly more lactate than other cells in the epidermis. Furthermore, lactate...
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