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Article

XPC silencing in normal human keratinocytes triggers metabolic alterations that drive the formation of squamous cell carcinomas.

The Journal of clinical investigation - 1 Jan 2011

Rezvani Hamid Reza, Kim Arianna L, Rossignol Rodrigue, Ali Nsrein, Daly Meaghan, Mahfouf Walid, Bellance Nadège, Taïeb Alain, de Verneuil Hubert, Mazurier Frédéric, Bickers David R

Abstract excerpt

DNA damage is a well-known initiator of tumorigenesis. Studies have shown that most cancer cells rely on aerobic glycolysis for their bioenergetics. We sought to identify a molecular link between genomic mutations and metabolic alterations in neoplastic transformation. We took advantage of the intrinsic genomic instability arising in xeroderma pigmentosum C (XPC). The XPC protein plays a key role in recognizing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21123941
DOI: 10.1172/JCI40087
PMCID: PMC3007130

Genes

XPC
AKT1
NOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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