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PTEN abnormalities predict poor outcome in children with T‐cell acute lymphoblastic leukemia treated according to ALL IC‐BFM protocols

8 Jan 2019

Abstract excerpt

Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy derived from T-cell precursors and represents 10% to15% of childhood acute lymphoblastic leukemia, the most common cancer in children. In T-ALL many recurrent molecular lesions, for example, alterations affecting NOTCH1, PI3K/PTEN/AKT/mTOR, or JAK-STAT signaling pathways, hold promise for genetic-based risk stratification and...

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PMID: 30614545
DOI: 10.1002/ajh.25396

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