Article
The presence of mutated and deleted PTEN is associated with an increased risk of relapse in childhood T cell acute lymphoblastic leukaemia treated with AIEOP-BFM ALL protocols.
British journal of haematology - 1 Sept 2018
Paganin Maddalena, Grillo Maria Francesca, Silvestri Daniela, Scapinello Greta, Buldini Barbara, Cazzaniga Giovanni, Biondi Andrea, Valsecchi Maria Grazia, Conter Valentino, Te Kronnie Geertruij, Basso Giuseppe
Abstract excerpt
Notwithstanding the improvement in treatment results for paediatric T cell acute lymphoblastic leukaemia (T-ALL) it remains important to understand if genetic aberrations influence therapy response. PTEN tumour suppressor gene inactivation is a frequent event in T-ALL but its effect on patient therapy response is debatable. We analysed the effect of the presence of mutated PTEN on outcome in 257 children with...
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