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Article

NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia.

Haematologica - 1 Jun 2013

Bandapalli Obul R, Zimmermann Martin, Kox Corinne, Stanulla Martin, Schrappe Martin, Ludwig Wolf-Dieter, Koehler Rolf, Muckenthaler Martina U, Kulozik Andreas E

Abstract excerpt

Despite improvements in treatment results for pediatric T-cell acute lymphoblastic leukemia, approximately 20% of patients relapse with dismal prognosis. PTEN inactivation and NOTCH1 activation are known frequent leukemogenic events but their effect on outcome is still controversial. We analyzed the effect of PTEN inactivation and its interaction with NOTCH1 activation on treatment response and long-term outcome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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Share to PTEN Phosphohydrolase

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Source

Open in PubMed Open full text

Identifiers

PMID: 23349303
DOI: 10.3324/haematol.2012.073585
PMCID: PMC3669450

Genes

NOTCH1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia.PMID 23349303Read ↗

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