Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.

doi:10.1200/JCO.2012.48.5292

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Article

Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Dec 2013

Trinquand Amélie, Tanguy-Schmidt Aline, Ben Abdelali Raouf, Lambert Jérôme, Beldjord Kheira, Lengliné Etienne, De Gunzburg Noémie, Payet-Bornet Dominique, Lhermitte Ludovic, Mossafa Hossein, Lhéritier Véronique, Bond Jonathan, Huguet Françoise, Buzyn Agnès, Leguay Thibaud, Cahn Jean-Yves, Thomas Xavier, Chalandon Yves, Delannoy André, Bonmati Caroline, Maury Sebastien, Nadel Bertrand, Macintyre Elizabeth, Ifrah Norbert, Dombret Hervé, Asnafi Vahid

Abstract excerpt

PURPOSE: The Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL) recently reported a significantly better outcome in T-cell acute lymphoblastic leukemia (T-ALL) harboring NOTCH1 and/or FBXW7 (N/F) mutations compared with unmutated T-ALL. Despite this, one third of patients with N/F-mutated T-ALL experienced relapse. PATIENTS AND METHODS: In a series of 212 adult T-ALLs included in the multicenter...

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PMID: 24166518
DOI: 10.1200/JCO.2012.48.5292

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PTEN
NOTCH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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