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Article

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.

Blood - 16 Jul 2009

Gutierrez Alejandro, Sanda Takaomi, Grebliunaite Ruta, Carracedo Arkaitz, Salmena Leonardo, Ahn Yebin, Dahlberg Suzanne, Neuberg Donna, Moreau Lisa A, Winter Stuart S, Larson Richard, Zhang Jianhua, Protopopov Alexei, Chin Lynda, Pandolfi Pier Paolo, Silverman Lewis B, Hunger Stephen P, Sallan Stephen E, Look A Thomas

Abstract excerpt

To more comprehensively assess the pathogenic contribution of the PTEN-PI3K-AKT pathway to T-cell acute lymphoblastic leukemia (T-ALL), we examined diagnostic DNA samples from children with T-ALL using array comparative genomic hybridization and sequence analysis. Alterations of PTEN, PI3K, or AK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinases

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 19458356
DOI: 10.1182/blood-2009-02-206722
PMCID: PMC2713461

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19458356-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.PMID 19458356Read ↗

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Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways.Semantic proximity Read ↗

Integrated Genomic Analyses Identify High-Risk Factors and Actionable Targets in T-Cell Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Genetic mutational profiling analysis of T cell acute lymphoblastic leukemia reveal mutant FBXW7 as a prognostic indicator for inferior survival.Semantic proximity Read ↗

The presence of mutated and deleted PTEN is associated with an increased risk of relapse in childhood T cell acute lymphoblastic leukaemia treated with AIEOP-BFM ALL protocols.Semantic proximity Read ↗

The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

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Impact of PTEN abnormalities on outcome in pediatric patients with T-cell acute lymphoblastic leukemia treated on the MRC UKALL2003 trial.Semantic proximity Read ↗

Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.Semantic proximity Read ↗

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