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Article

The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia.

Haematologica - 1 Sept 2012

Zuurbier Linda, Petricoin Emanuel F, Vuerhard Maartje J, Calvert Valerie, Kooi Clarissa, Buijs-Gladdines Jessica G C A M, Smits Willem K, Sonneveld Edwin, Veerman Anjo J P, Kamps Willem A, Horstmann Martin, Pieters Rob, Meijerink Jules P P

Abstract excerpt

BACKGROUND: PI3K/AKT pathway mutations are found in T-cell acute lymphoblastic leukemia, but their overall impact and associations with other genetic aberrations is unknown. PTEN mutations have been proposed as secondary mutations that follow NOTCH1-activating mutations and cause cellular resistance to γ-secretase inhibitors. DESIGN AND METHODS: The impact of PTEN, PI3K and AKT aberrations was studied in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphatidylinositol 3-Kinases

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-akt

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Source

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Identifiers

PMID: 22491738
DOI: 10.3324/haematol.2011.059030
PMCID: PMC3436243

Genes

PTEN
NOTCH1
TLX3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia.PMID 22491738Read ↗

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The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

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Single-cell profiling of pediatric T-cell acute lymphoblastic leukemia: Impact of PTEN exon 7 mutation on PI3K/Akt and JAK-STAT signaling pathways.Semantic proximity Read ↗

The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group.Semantic proximity Read ↗

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