NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup of patients.

doi:10.1182/blood.2023023754

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup of patients.

Blood - 10 Oct 2024

Simonin Mathieu, Vasseur Loïc, Lengliné Etienne, Lhermitte Ludovic, Cabannes-Hamy Aurélie, Balsat Marie, Schmidt Aline, Dourthe Marie-Emilie, Touzart Aurore, Graux Carlos, Grardel Nathalie, Cayuela Jean-Michel, Arnoux Isabelle, Gandemer Virginie, Huguet Françoise, Ducassou Stéphane, Lhéritier Véronique, Chalandon Yves, Ifrah Norbert, Dombret Hervé, Macintyre Elizabeth, Petit Arnaud, Rousselot Philippe, Lambert Jérôme, Baruchel André, Boissel Nicolas, Asnafi Vahid

Abstract excerpt

ABSTRACT: We previously reported a better outcome in adult and pediatric T-cell acute lymphoblastic leukemia (T-ALL) harboring NOTCH1 and/or FBXW7 mutations without alterations of K-N-RAS and PTEN genes. Availability of high-throughput next-generation sequencing (NGS) strategies led us to refine the outcome prediction in T-ALL. Targeted whole-exome sequencing of 72 T-ALL-related oncogenes was performed in 198...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clinical Trials as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to F-Box-WD Repeat-Containing Protein 7

Share to High-Throughput Nucleotide Sequencing

Share to Infant

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Prognosis

Share to Receptor, Notch1

Share to Risk Assessment

Source

Open in PubMed

Identifiers

PMID: 38848537
DOI: 10.1182/blood.2023023754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NGS-based stratification refines the risk stratification in T-ALL and identifies a very-high-risk subgroup of patients.PMID 38848537Read ↗

Molecular classification improves risk assessment in adult BCR-ABL1-negative B-ALL.Semantic proximity Read ↗

Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study.Semantic proximity Read ↗

Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicineSemantic proximity Read ↗

Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes.Semantic proximity Read ↗

Genomic Subclassification and Risk Stratification of ALL.Semantic proximity Read ↗

The RAS-signaling-pathway-mutation-related prognosis in B-cell acute lymphoblastic leukemia: A report from South China children's leukemia group.Semantic proximity Read ↗

Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemiaSemantic proximity Read ↗

Optimized outcome prediction of oncogenetic mutations in non-early T-cell precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

T-cell acute lymphoblastic leukaemia: subtype prevalence, clinical outcome, and emerging targeted treatmentsSemantic proximity Read ↗

Next-Generation Sequencing in Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Clinical Relevance and Applicability of the 2022 World Health Organization Classification of Childhood B Lymphoblastic Leukemia in the Context of MRD-Directed TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.