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Broad CD8+ T cell cross-recognition of distinct influenza A strains in humans

17 Dec 2018

Abstract excerpt

Abstract Newly-emerged and vaccine-mismatched influenza A viruses (IAVs) result in a rapid global spread of the virus due to minimal antibody-mediated immunity. In that case, established CD8+T-cells can reduce disease severity. However, as mutations occur sporadically within immunogenic IAV-derived T-cell peptides, understanding of T-cell receptor (TCRαβ) cross-reactivity towards IAV variants is needed for a...

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PMID: 30575715
DOI: 10.1038/s41467-018-07815-5

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