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Article

Cross-reactive CD8 <sup>+</sup> T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses

28 Jun 2010

Abstract excerpt

Preexisting T-cell immunity directed at conserved viral regions promotes enhanced recovery from influenza virus infections, with there being some evidence of cross-protection directed at variable peptides. Strikingly, many of the immunogenic peptides derived from the current pandemic A(H1N1)-2009 influenza virus are representative of the catastrophic 1918 "Spanish flu" rather than more recent "seasonal" strains....

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PMID: 20616031
DOI: 10.1073/pnas.1007270107

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