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Article

Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold.

PLoS pathogens - 12 Aug 2010

Valkenburg Sophie A, Gras Stephanie, Guillonneau Carole, La Gruta Nicole L, Thomas Paul G, Purcell Anthony W, Rossjohn Jamie, Doherty Peter C, Turner Stephen J, Kedzierska Katherine

Abstract excerpt

Emergence of a new influenza strain leads to a rapid global spread of the virus due to minimal antibody immunity. Pre-existing CD8(+) T-cell immunity directed towards conserved internal viral regions can greatly ameliorate the disease. However, mutational escape within the T cell epitopes is a su...

Read the complete abstract on PubMed

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Share to Antigens, Viral
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epitopes, T-Lymphocyte

Share to Influenza A virus

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Share to Receptors, Antigen, T-Cell

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Source

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Identifiers

PMID: 20711359
DOI: 10.1371/journal.ppat.1001039
PMCID: PMC2920842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20711359-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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