Article
Cross-allele cytotoxic T lymphocyte responses against 2009 pandemic H1N1 influenza A virus among HLA-A24 and HLA-A3 supertype-positive individuals.
Journal of virology - 1 Dec 2012
Liu Jun, Zhang Shihong, Tan Shuguang, Yi Yong, Wu Bin, Cao Bin, Zhu Fengcai, Wang Chen, Wang Hua, Qi Jianxun, Gao George F
Abstract excerpt
Lack of a universal vaccine against all serotypes of influenza A viruses and recent progress on T cell-related vaccines against influenza A virus illuminate the important role of human leukocyte antigen (HLA)-restricted cytotoxic T lymphocytes (CTLs) in anti-influenza virus immunity. However, the diverse HLA alleles among humans complicate virus-specific cellular immunity research, and elucidation of cross-HLA...
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