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Article

Knockdown of BNIP3L or SQSTM1 alters cellular response to mitochondria target drugs

19 Dec 2018

Abstract excerpt

Macroautophagy/autophagy, a pathway by which cellular components are sequestered and degraded in response to homeostatic and cell stress-related signals, is required to preserve hematopoietic stem and progenitor cell function. Loss of chromosomal regions carrying autophagy genes and decreased autophagy gene expression are characteristic of acute myeloid leukemia (AML) cells. Deficiency of autophagy proteins is...

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PMID: 30563411
DOI: 10.1080/15548627.2018.1558002

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