Article

Autophagy inhibition induces AML cell death and enhances the efficacy of chemotherapy under hypoxia

2024-11-26

Abstract excerpt

Outcomes of relapsed/refractory acute myeloid leukemia (AML) are poor, and strategies to improve outcomes are urgently needed. One important factor promoting relapse and chemoresistance is the ability of AML cells to thrive in vivo within an intrinsically hypoxic bone marrow microenvironment. Here we show that human AML cells exhibit enhanced autophagy, specifically mitophagy (i.e., increased accumulation of mitoc...

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Literature Corpus work: a79bf631-ac48-5ebe-aad4-68104c548459
DOI: 10.1101/2024.11.24.625107

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