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Article

Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy

22 Apr 2022

Abstract excerpt

Cisplatin (CDDP) is commonly used to treat a multitude of tumors including sarcomas, ovarian and cervical cancers. Despite recent investigations allowed to improve chemotherapy effectiveness, the molecular mechanisms underlying the development of CDDP resistance remain a major goal in cancer research. Here, we show that mitochondrial morphology and autophagy are altered in different CDDP resistant cancer cell...

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PMID: 35459212
DOI: 10.1038/s41419-022-04741-9

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