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Article

Autophagy in the pathogenesis of myelodysplastic syndrome and acute myeloid leukemia

1 Jun 2011

Abstract excerpt

Autophagy is a conserved cellular pathway responsible for the sequestration of spent organelles and protein aggregates from the cytoplasm and their delivery into lysosomes for degradation. Autophagy plays an important role in adaptation to starvation, in cell survival, immunity, development and cancer. Recent evidence in mice suggests that autophagic defects in hematopoietic stem cells (HSCs) may be implicated in...

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PMID: 21512311
DOI: 10.4161/cc.10.11.15673

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