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Article

Regulation of Mitochondrial Integrity, Autophagy and Cell Survival by BNIP3

26 Nov 2007

Abstract excerpt

Understanding the role of BNIP3 in the systemic response to hypoxia has been complicated by conflicting results that indicate on the one hand that BNIP3 promotes cell death, and other data, including our own that BNIP3 is not sufficient for cell death, but rather plays a critical role in hypoxia-induced autophagy. This work suggests that rather than promoting death, BNIP3 may actually allow survival either by...

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PMID: 17786027
DOI: 10.4161/auto.4892

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