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Article

Mechanisms of aromatase inhibitor resistance.

Nature reviews. Cancer - 1 May 2015

Ma Cynthia X, Reinert Tomás, Chmielewska Izabela, Ellis Matthew J

Abstract excerpt

Oestrogen receptor-positive (ER(+)) breast cancer is a major cause of cancer death in women. Although aromatase inhibitors suppress the function of ER and reduce the risk of recurrence, therapeutic resistance is common and essentially inevitable in advanced disease. This Review considers both genomic and cell biological explanations as to why ER(+) breast cancer cells persist, progress and cause an incurable,...

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Source

Identifiers

PMID: 25907219
DOI: 10.1038/nrc3920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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