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Article

Molecular Changes During Breast Cancer and Mechanisms of Endocrine Therapy Resistance.

Progress in molecular biology and translational science - 1 Jan 2016

Radhi S

Abstract excerpt

Estrogen receptors (ERs) are expressed in 75% of breast cancers. ERs and their estrogen ligands play a key role in the development and progression of breast cancer. ERs have a genomic activity involving direct modulation of expression of genes vital to cell growth and survival by their classic nuclear receptors. The nongenomic activity is mediated by membrane receptor tyrosine kinases that activate signaling...

Topics

Breast Neoplasms
Drug Resistance, Neoplasm
Epigenesis, Genetic
Female
Hormones
Humans
Mutation
Receptors, Estrogen

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 27865467
DOI: 10.1016/bs.pmbts.2016.09.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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