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Article

An “Omics” Approach to Determine the Mechanisms of Acquired Aromatase Inhibitor Resistance

20 Feb 2011

Abstract excerpt

Aromatase inhibitors (AIs) are the major types of drugs to treat hormone-dependent breast cancer. Although these drugs work effectively, cancer still recurs in many patients after treatment as a result of acquired resistance to the AIs. To characterize the resistant mechanisms, a set of MCF-7aro cell lines that acquired resistance to the AIs was generated. Through an "Omics" approach, we found that the resistance...

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PMID: 21332390
DOI: 10.1089/omi.2010.0097

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