Article

The Androgen Receptor is a Tumour Suppressor in Estrogen Receptor Positive Breast Cancer

2020-09-01

Abstract excerpt

<title>Abstract</title> <p>Antagonistic sex hormone activity occurs in mammary gland development, whereby estrogen stimulates and androgen inhibits post-pubertal growth, but the mechanistic basis of this is largely unknown. Whether sex hormone antagonism occurs in the context of breast cancer is also unclear. The estrogen receptor alpha (ER) unequivocally drives the majority of breast malignancies, but the role o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: daedf251-2eb7-5392-a5a3-7d87f0216ee7
DOI: 10.21203/rs.3.rs-62718/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Androgen Receptor is a Tumour Suppressor in Estrogen Receptor Positive Breast CancerDOI 10.21203/rs.3.rs-62718/v1Read

Pushing estrogen receptor around in breast cancerSemantic proximity Read

An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen.Semantic proximity Read

Deciphering Steroid Receptor Crosstalk in Hormone-Driven CancersSemantic proximity Read

Progesterone receptor isoforms, agonists and antagonists differentially reprogram estrogen signalingSemantic proximity Read

Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer.Semantic proximity Read

Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast CancerSemantic proximity Read

Nuclear Estrogen Receptors in Prostate Cancer: From Genes to FunctionSemantic proximity Read

Multiple Molecular Subtypes of Triple-Negative Breast Cancer Critically Rely on Androgen Receptor and Respond to Enzalutamide <i>In Vivo</i>Semantic proximity Read

Estrogen Receptor Alpha Mutations, Truncations, Heterodimers, and Therapies.Semantic proximity Read

Looking beyond the ER, PR, and HER2: what’s new in the ARsenal for combating breast cancer?Semantic proximity Read

Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancerSemantic proximity Read

Modulation of estrogen receptor alpha activity and expression during breast cancer progression.Semantic proximity Read