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Toll-like receptor chaperone HSP90B1 and the immune response to Mycobacteria

14 Dec 2018

Abstract excerpt

RATIONALE: HSP90B1, also known as gp96, is a chaperone for multiple Toll-like receptors (TLRs) and is necessary for TLR-mediated inflammatory responses in murine myeloid cells. The molecule is also expressed in T-cells though its specific role is unknown. We hypothesized that human HSP90B1 regulates monocyte and T-cell responses to Mycobacterium tuberculosis (Mtb) and bacilli Calmette-Guerin (BCG) and that its...

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PMID: 30550567
DOI: 10.1371/journal.pone.0208940

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