Article

CNBP, REL, and BHLHE40 variants are associated with IL-12 and IL-10 responses and tuberculosis risk

2021-03-06

Abstract excerpt

<h4>Rationale</h4> The major human genes regulating M. tuberculosis (Mtb)-induced immune responses and tuberculosis (TB) susceptibility are poorly understood. Although IL-12 and IL-10 are critical for TB pathogenesis, the genetic factors that regulate their expression are unknown. CNBP, REL, and BHLHE40 are master regulators of IL-12 and IL-10 signaling. <h4>Objectives</h4> To determine whether common human geneti...

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Literature Corpus work: 2471d978-2be1-5b10-9e5a-9ea4e4362ce4
DOI: 10.1101/2021.03.03.21252797

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