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Article

BCG induced innate immune response heterogeneity and susceptibility to pediatric tuberculosis.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2025

Anterasian Christine, Gela Anele, Mwambene Temwa-Dango, Shah Javeed A, Ivie Josh, Dill-McFarland Kimberly A, Hanekom Willem A, Kiritsy Michael C, Sassetti Christopher M, Musvosvi Munyaradzi, Hatherill Mark, Scriba Thomas J, Hawn Thomas R

Abstract excerpt

Although immune responses to bacillus Calmette-Guerin (BCG)-vaccination and susceptibility to pediatric tuberculosis (TB) vary across individuals, the underlying cellular mechanism regulating this heterogeneity is poorly understood. We used a nested case-control study with a 2-yr prospective observation period to examine whether genetic variation is associated with BCG-induced innate immune responses and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40174917
DOI: 10.1093/jimmun/vkae062
PMCID: PMC12124979

Genes

CD40
IGLL1
PDE8A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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