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PCNA-mediated stabilization of E3 ligase RFWD3 at the replication fork is essential for DNA replication

10 Dec 2018

Abstract excerpt

RING finger and WD repeat domain-containing protein 3 (RFWD3) is an E3 ligase known to facilitate homologous recombination by removing replication protein A (RPA) and RAD51 from DNA damage sites. Further, RPA-mediated recruitment of RFWD3 to stalled replication forks is essential for interstrand cross-link repair. Here, we report that in unperturbed human cells, RFWD3 localizes at replication forks and associates...

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PMID: 30530694
DOI: 10.1073/pnas.1814521115

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