Article
RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.
Molecular cell - 15 Oct 2015
Elia Andrew E H, Wang David C, Willis Nicholas A, Boardman Alexander P, Hajdu Ildiko, Adeyemi Richard O, Lowry Elizabeth, Gygi Steven P, Scully Ralph, Elledge Stephen J
Abstract excerpt
We have used quantitative proteomics to profile ubiquitination in the DNA damage response (DDR). We demonstrate that RPA, which functions as a protein scaffold in the replication stress response, is multiply ubiquitinated upon replication fork stalling. Ubiquitination of RPA occurs on chromatin, involves sites outside its DNA binding channel, does not cause proteasomal degradation, and increases under conditions...
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