Article

HIV-2 evades restriction by ZAP through adaptations in the U3 LTR region despite increased CpG levels

2024-10-13

Abstract excerpt

Simian immunodeficiency viruses infecting sooty mangabeys (SIVsmm) gave rise to nine groups of human immunodeficiency virus type 2 (HIV-2). Two of these (A and B) spread substantially with an estimated 1- 2 million individuals affected. The evolutionary adaptations that facilitated HIV-2 spread in humans are still poorly understood. Here, we report that diverse SIVsmm strains efficiently infect primary human T cel...

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Literature Corpus work: 44214079-6bc2-55a9-9786-16ef766e935f
DOI: 10.1101/2024.10.13.618097

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HIV-2 evades restriction by ZAP through adaptations in the U3 LTR region despite increased CpG levelsDOI 10.1101/2024.10.13.618097Read

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