Back to search

Article

Genome‑wide replication‑competent HIV‑guided CRISPR screen identifies DNA metabolism/repair regulators as antiviral factors

2026-02-20

Abstract excerpt

<title>Abstract</title> <p>Innate antiviral factors are critical components of host defense. However, many physiologically relevant mechanisms restricting HIV-1 replication remain to be identified. To uncover such factors, we developed an HIV-1–guided CRISPR-Cas9 screen using replication-competent HIV-1 libraries encoding 77,441 distinct sgRNAs targeting all annotated human genes. Viral propagation in the presenc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a527557e-4bec-57d4-a6c6-b03b0c929144
DOI
10.21203/rs.3.rs-8668200/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genome‑wide replication‑competent HIV‑guided CRISPR screen identifies DNA metabolism/repair regulators as antiviral factorsDOI 10.21203/rs.3.rs-8668200/v1
Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein NefSemantic proximity
Bloom syndrome helicase is required for efficient HIV-1 reverse transcription in macrophagesSemantic proximity
A CRISPR-Cas9 Genome Engineering Platform in Primary CD4+ T Cells for the Interrogation of HIV Host FactorsSemantic proximity
A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIVSemantic proximity
CRISPR-Cas based antiviral strategies against HIV-1Semantic proximity
A Virus-Packageable CRISPR System Identifies Host Dependency Factors Across Multiple HIV-1 StrainsSemantic proximity
A CRISPR-Cas Cure for HIV/AIDSSemantic proximity
CRISPR-Cas13a Inhibits HIV-1 InfectionSemantic proximity
The therapeutic application of CRISPR/Cas9 technologies for HIVSemantic proximity
Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene EditingSemantic proximity
Elimination of infectious HIV DNA by CRISPR–Cas9Semantic proximity
A Virus-Packageable CRISPR Screen Identifies Host Factors Mediating Interferon Inhibition of HIVSemantic proximity
Select a neighboring publication to make it the new centre.