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Interferon inhibits a model RNA virus via a limited set of inducible effector genes

27 Jul 2023

Abstract excerpt

Interferons control viral infection by inducing the expression of antiviral effector proteins encoded by interferon‐stimulated genes (ISGs). The field has mostly focused on identifying individual antiviral ISG effectors and defining their mechanisms of action. However, fundamental gaps in knowledge about the interferon response remain. For example, it is not known how many ISGs are required to protect cells from...

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PMID: 37497756
DOI: 10.15252/embr.202356901

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