Article

Quantitative analysis of the ubiquitin-proteasome system under proteolytic and folding stressors

2019-09-24

Abstract excerpt

Aging, disease, and environmental stressors are associated with failures in the ubiquitin-proteasome system (UPS), yet a quantitative understanding of how stressors affect the proteome and how the UPS responds is lacking. Here we assessed UPS performance and adaptability in yeast under stressors using quantitative measurements of misfolded substrate stability and stress-dependent UPS regulation by the transcriptio...

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Literature Corpus work: 17a105e6-c12b-5faf-a867-30a1b0c6a627
DOI: 10.1101/780676

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