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Article

Targeting the Ribosome Biogenesis Key Molecule Fibrillarin to Avoid Chemoresistance

3 Dec 2018

Abstract excerpt

BACKGROUND: Inherent or acquired chemo resistance in cancer patients has been a perpetual limitation in cancer treatment. Expanding knowledge on essential cellular processes opens a new window for therapeutic targeting. Ribosome biogenesis is a process that shows potential due to its fundamental role in cell development and contribution to tumorigenesis as a result of its upregulation. Inhibiting components of...

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PMID: 30501594
DOI: 10.2174/0929867326666181203133332

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