Article

Ribosome biogenesis is a therapeutic vulnerability in paediatric neuroblastoma

2025-03-28

Abstract excerpt

<h4>Background</h4> Neuroblastoma is a heterogeneous malignant paediatric tumor with prognosis depending on patient age and disease stage. Current treatment strategies rely on four key diagnostic criteria: age, histological stage, MYCN gene status, and genomic profile. It has been reported that MYC oncogenic activity depends on ribosome biogenesis, whose hyperactivation in cancer cells supports their high prolif...

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Literature Corpus work: ecd26c98-96a2-541e-883f-6d6126d373b2
DOI: 10.1101/2025.03.26.645392

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